Progression of liver fibrosis and associated factors among chronic hepatitis B patients at a general hospital in Northern Vietnam

Ngoc Minh Luu

Thi Kim Thuy Nguyen, Thu Trang Vu, Thai Son Dinh, Ngoc Hoat Luu, Thi Thanh Toan Do, Van Son Nguyen, Thi Bich Van Ha, Dinh Chuc Nguyen, Thi Huong Tran, Thi Thuy Hang Phung, Xuan Phuong Duong, Quynh Long Khuong, Thi Thu Trang Nguyen, Yu Mon Saw, Thi Ngoc Anh Hoang, Thi Nh

liver fibrosis, associated factors, APRI index, mixed-effect model, hepatitis B virus infection

Evaluation of liver fibrosis is necessary to make the therapeutic decision and assess the prognosis of CHB patients. The current study aimed to describe the progression and identify some influencing factors in patients with chronic hepatitis B at a General Hospital in Northern Vietnam. The longitudinal study included 55 eligible subjects diagnosed Hepatitis-B-virus. Dependent variable was the aspartate aminotransferase/platelet ratio index and we collected some demographic variables and disease related and behaviour variables. Bayesian Model Averaging was used to select variables into model. Mixed-effect linear models were used to evaluate the change of the aspartate aminotransferase/platelet ratio index over time and identify related factors. the aspartate aminotransferase/platelet ratio index differences between examinations, age of participants, working status were statistically significant. This pattern indicated that the average the aspartate aminotransferase/platelet ratio index of the population decreased by 0.005 (95% CI=-0.009; –0.001) after each patient’s visit, and increased by 0.013 if the patient’s age increased by 1 year (95% CI=0.005; 0.0219). For non-working patients, the aspartate aminotransferase/platelet ratio index was lower, coefficient was –0.054 (95% CI=-0.108; 0.001). Other variables such as gender, education level, time for disease detection, drinking tea, alcohol consumption, forgetting to take medicine and the aspartate aminotransferase/platelet ratio index were not significantly different. The study showed that the majority of study subjects had average the aspartate aminotransferase/platelet ratio index, and were relatively well controlled and treated during the study. Age and working status are factors that influence the the aspartate aminotransferase/platelet ratio index

2022

10p

eng

Nagoya J Med Sci.

19-28

84